SYNTHESIS OF SUBSTITUTED 2,1-BENZISOTHIAZOLES

被引：29

作者：

DAVIS, M

WHITE, AW

机构：

[1] Department of Chemistry, La Trobe University, Bundoora

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1969年 / 34卷 / 10期

关键词：

D O I：

10.1021/jo01262a041

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2,1-Benzisothiazole (3) and nine substituted 2,1-benzisothiazoles have been synthesized by the reaction of thionylchloride with an appropriately substituted 2-aminotoluene (o-toluidine) in ylene at reflux temperature. Yields ashigh as 80% may be obtained. Liquid benzisothiazoles are conveniently isolated as picrate salts. The mechanism of formation of 3 is discussed and an intermediate benzylidenesulfinyl compound(8) is postulated. Nmr and uv data arepresented. © 1969, American Chemical Society. All rights reserved.

引用

页码：2985 / &

共 20 条

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