MODIFIED BASES CHARACTERIZED IN INTACT DNA BY MASS-ANALYZED ION KINETIC-ENERGY SPECTROMETRY

被引：35

作者：

SCHOEN, AE ^{[1
]}

COOKS, RG ^{[1
]}

WIEBERS, JL ^{[1
]}

机构：

[1] PURDUE UNIV,DEPT BIOL SCI,W LAFAYETTE,IN 47907

来源：

SCIENCE | 1979年 / 203卷 / 4386期

关键词：

D O I：

10.1126/science.570725

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Pyrolysis of DNA into a chemical ionization source yields protonated bases and other base-containing ions. Kinetic energy spectra allow the characterization of the bases 5-methylcytosine and 1-methyladenine from underivatized salmon sperm DNA. Isomeric bases are distinguishable with this technique.

引用

页码：1249 / 1251

页数：3

共 19 条

[1]

ARBER W, 1974, PROG NUCLEIC ACID RE, V14, P31

[2] DESIGN AND PERFORMANCE OF A MASS ANALYZED ION KINETIC-ENERGY (MIKE) SPECTROMETER [J].