QUINALDOPEPTIN, A NOVEL ANTIBIOTIC OF THE QUINOMYCIN FAMILY

被引:38
作者
TODA, S
SUGAWARA, K
NISHIYAMA, Y
OHBAYASHI, M
OHKUSA, N
YAMAMOTO, H
KONISHI, M
OKI, T
机构
[1] Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Tokyo 153, 2-9-3 Shimo-meguro, Meguro-ku
关键词
D O I
10.7164/antibiotics.43.796
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Quinaldopeptin, a new type of quinomycin antibiotic, was isolated from the culture of Streptoverticillium album strain Q132-6. The antibiotic exhibited strong in vitro antimicrobial and cytotoxic activity and significantly prolonged the survival time of mice inoculated with a murine tumor. Quinaldopeptin is a symmetric cyclic peptide linked only by peptide bonds and differs from known antibiotics of the quinomycin family by the lack of ester linkage. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
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页码:796 / 808
页数:13
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