QUINALDOPEPTIN, A NOVEL ANTIBIOTIC OF THE QUINOMYCIN FAMILY

被引：38

作者：

TODA, S

SUGAWARA, K

NISHIYAMA, Y

OHBAYASHI, M

OHKUSA, N

YAMAMOTO, H

KONISHI, M

OKI, T

机构：

[1] Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Tokyo 153, 2-9-3 Shimo-meguro, Meguro-ku

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 07期

关键词：

D O I：

10.7164/antibiotics.43.796

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Quinaldopeptin, a new type of quinomycin antibiotic, was isolated from the culture of Streptoverticillium album strain Q132-6. The antibiotic exhibited strong in vitro antimicrobial and cytotoxic activity and significantly prolonged the survival time of mice inoculated with a murine tumor. Quinaldopeptin is a symmetric cyclic peptide linked only by peptide bonds and differs from known antibiotics of the quinomycin family by the lack of ester linkage. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：796 / 808

页数：13

共 15 条

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