DETERMINATION OF QUININE AND QUINIDINE BY CONTINUOUS-FLOW CHEMILUMINESCENCE

被引:53
作者
KOUKLI, II [1 ]
CALOKERINOS, AC [1 ]
机构
[1] UNIV ATHENS,ANALYT CHEM LAB,104 SOLONOS ST,GR-10680 ATHENS,GREECE
关键词
Pharmaceuticals; Quinidine; Quinine;
D O I
10.1016/S0003-2670(00)83351-6
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A rapid and precise continuous-flow method is described for the determination of quinine and quinidine (5.00-500 μg ml-1) which is based on the sensitizing effect of the compounds on the chemiluminescent oxidation of sulphite by cerium(IV). When applied to tablets, the procedure is relatively free from interferences from common excipients. The results obtained for the assay of commercial formulations compared well with those obtained by an official method and demonstrated good accuracy and precision. © 1990.
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页码:463 / 468
页数:6
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