A QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP STUDY AND ECOTOXICOLOGICAL RISK QUOTIENT FOR THE PROTECTION FROM CHEMICAL POLLUTION

被引：18

作者：

YOSHIOKA, Y

OSE, Y

机构：

[1] Gifu College of Medical Technology, Seki, Gifu, 501-32, 795-1, Aza-nagamine, Ichihiraga

[2] Gifu City Women's College, Gifu City, Gifu, 500, 2693, Nagara‐Fukumitsu

来源：

ENVIRONMENTAL TOXICOLOGY AND WATER QUALITY | 1993年 / 8卷 / 01期

关键词：

D O I：

10.1002/tox.2530080109

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

A quantitative structure-activity relationship study is carried out with use of the toxicity (LC50) of the various kinds of fish obtained from the references. The equation obtained contained the parameters of molecular weight (MW) and mean ionization potential (IPBAR): log(1/LC50) = 28.665 + 0.01095MW - 2.570IPBAR (R2 = 0.695, n = 581). This equation could estimate the toxicity of the chemicals detected in the environment of Japan by Environment Agency (r = 0.80, n = 53). In order to evaluate the hazardousness, we propose the Ecotoxicological Risk Quotient (ERQ): ERQ(c) = -log Concentration in the environment/Effective concentration in the test ERQ(a) = -logSIGMA Concentration in the environment/Effective concentration in the test ERQ(c) and ERQ(a) are the indices of the hazardousness of a chemical and chemicals in an area, respectively. ERQ could explain the status of pollution in water environment of Japan.

引用

页码：87 / 101

页数：15

共 34 条

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