REGULATION OF C-FOS PROTOONCOGENE EXPRESSION BY GROWTH-HORMONE - PROTEIN-SYNTHESIS IS NOT REQUIRED FOR DOWN-REGULATION

被引：2

作者：

BARCELLINICOUGET, S

DOGLIO, A

DANI, C

机构：

来源：

ENDOCRINOLOGY | 1993年 / 132卷 / 04期

关键词：

D O I：

10.1210/en.132.4.1875

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Growth hormone (GH) has been previously shown in Ob1771 adipose cells to transiently stimulate the expression of the c-fos gene by a protein kinase C (PKC)-dependent pathway. This regulation takes place al a transcriptional level. In the presence of cycloheximide (CHX), stimulation by PKC activators or by serum leads to a 'superinduction' of the c-fos gene. In contrast, upon GH stimulation in the presence of CHX, no superinduction takes place and neither prolonged transcription nor mRNA stabilization are observed.

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页码：1875 / 1877

页数：3

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