GENES FOR BONE MORPHOGENETIC PROTEINS ARE DIFFERENTIALLY TRANSCRIBED IN EARLY AMPHIBIAN EMBRYOS

被引：129

作者：

NISHIMATSU, S ^{[1
]}

SUZUKI, A ^{[1
]}

SHODA, A ^{[1
]}

MURAKAMI, K ^{[1
]}

UENO, N ^{[1
]}

机构：

[1] UNIV TSUKUBA, INST APPL BIOCHEM, TSUKUBA, IBARAKI 305, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 186卷 / 03期

关键词：

D O I：

10.1016/S0006-291X(05)81574-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have previously demonstrated that activin, a member of the TGF-β family, has a potent mesoderm-inducing activity in Xenopus embryos. In the course of screening for activin-related genes from Xenopus, we have cloned cDNAs for Xenopus homologue of BMP-2, -4 and -7. Northern blot analysis revealed that these BMP genes are maternally encoded and differentially regulated after fertilization. Alkaline phosphatase-inducing assay using the recombinant BMP proteins has shown that at least BMP-2 and -4 have similar activity to mammalian counterparts. © 1992 Academic Press, Inc.

引用

页码：1487 / 1495

页数：9

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