COMPARATIVE GASTROINTESTINAL TRANSIT OF PELLET SYSTEMS OF VARYING DENSITY

被引:89
作者
CLARKE, GM
NEWTON, JM
SHORT, MB
机构
[1] UNIV LONDON, SCH PHARM, LONDON WC1N 1AX, ENGLAND
[2] UCL, DEPT MED PHYS, LONDON WC1E 6AD, ENGLAND
关键词
DENSITY; GASTRIC EMPTYING; GASTROINTESTINAL TRANSIT; RADIOLABELING; PELLET; TC-99M; GAMMA SCINTIGRAPHY;
D O I
10.1016/0378-5173(94)00200-O
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Model placebo multiple unit oral dosage forms were prepared by the processes of extrusion and spheronisation. The non-invasive technique of gamma scintigraphy was used to monitor the gastrointestinal transit of these radiolabelled dosage forms. Standard sized units (1.18-1.40 mm) of density 2.0 and 2.4 g cm(-3) were compared with similarly sized control units of 1.5 g cm(-3). Each density was tested separately in eight healthy fasted male subjects. The results showed no differences in the gastrointestinal transit of the three formulations as measured by each of several parameters selected to describe the process. However, the results did reveal some interesting features of the gastric emptying process, and provide further information regarding the critical density at which a prolongation of gastric emptying occurs.
引用
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页码:1 / 11
页数:11
相关论文
共 34 条
[1]   GASTROINTESTINAL TRANSIT OF PELLET SYSTEMS IN ILEOSTOMY SUBJECTS AND THE EFFECT OF DENSITY [J].
BECHGAARD, H ;
CHRISTENSEN, FN ;
DAVIS, SS ;
HARDY, JG ;
TAYLOR, MJ ;
WHALLEY, DR ;
WILSON, CG .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1985, 37 (10) :718-721
[2]   DISTRIBUTION OF PELLETS IN GASTROINTESTINAL-TRACT - INFLUENCE ON TRANSIT-TIME EXERTED BY DENSITY OR DIAMETER OF PELLETS [J].
BECHGAARD, H ;
LADEFOGED, K .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1978, 30 (11) :690-692
[3]  
BOGENTOFT C, 1982, RADIONUCLIDE IMAGING, P294
[4]   THE USE OF GAMMA-SCINTIGRAPHY TO FOLLOW THE GASTROINTESTINAL TRANSIT OF PHARMACEUTICAL FORMULATIONS [J].
CHRISTENSEN, FN ;
DAVIS, SS ;
HARDY, JG ;
TAYLOR, MJ ;
WHALLEY, DR ;
WILSON, CG .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1985, 37 (02) :91-95
[5]   MEASUREMENT OF MEAN TRANSIT-TIME OF DIETARY RESIDUE THROUGH HUMAN GUT [J].
CUMMINGS, JH ;
JENKINS, DJA ;
WIGGINS, HS .
GUT, 1976, 17 (03) :210-218
[6]   THE INVIVO EVALUATION OF AN OSMOTIC DEVICE (OSMET) USING GAMMA SCINTIGRAPHY [J].
DAVIS, SS ;
HARDY, JG ;
TAYLOR, MJ ;
STOCKWELL, A ;
WHALLEY, DR ;
WILSON, CG .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1984, 36 (11) :740-742
[7]   THE EFFECT OF DENSITY ON THE GASTRIC-EMPTYING OF SINGLE-UNIT AND MULTIPLE-UNIT DOSAGE FORMS [J].
DAVIS, SS ;
STOCKWELL, AF ;
TAYLOR, MJ ;
HARDY, JG ;
WHALLEY, DR ;
WILSON, CG ;
BECHGAARD, H ;
CHRISTENSEN, FN .
PHARMACEUTICAL RESEARCH, 1986, 3 (04) :208-213
[8]   GASTROINTESTINAL TRANSIT OF A CONTROLLED-RELEASE PELLET FORMULATION OF TIAPROFENIC ACID AND THE EFFECT OF FOOD [J].
DAVIS, SS ;
KHOSLA, R ;
WILSON, CG ;
WASHINGTON, N .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1987, 35 (03) :253-258
[9]   GASTROINTESTINAL TRANSIT OF A CONTROLLED RELEASE NAPROXEN TABLET FORMULATION [J].
DAVIS, SS ;
HARDY, JG ;
WILSON, CG ;
FEELY, LC ;
PALIN, KJ .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1986, 32 (01) :85-90
[10]   TRANSIT OF PHARMACEUTICAL DOSAGE FORMS THROUGH THE SMALL-INTESTINE [J].
DAVIS, SS ;
HARDY, JG ;
FARA, JW .
GUT, 1986, 27 (08) :886-892