ENANTIOSELECTIVE PERMEATION OF ALPHA-AMINO-ACID ISOMERS THROUGH POLY(AMINO ACID)-DERIVED MEMBRANES

被引:116
作者
MARUYAMA, A
ADACHI, N
TAKATSUKI, T
TORII, M
SANUI, K
OGATA, N
机构
[1] Department of Chemistry, Faculty of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku
关键词
D O I
10.1021/ma00212a027
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Poly(L-glutamates) having amphiphilic side chains of (n-nonylphenoxy)oligo(oxyethylene) (NONx-PLG) were observed to possess potential properties as membrane materials for resolving optical isomers of a-amino acids. Permeation rate ratios of >8.0 for the d isomer to l isomer of tyrosine and tryptophan were achieved. Permeation of amino acids for times >500 h did not cause any drop in selectivity. Operating temperature considerably affected the permselectivity of the isomers. Since NONx-PLG adopted mainly an a-helical structure in its cast film and formed a liquid crystalline (nematic) type mesophase, this ordered structure of poly(amino acid) derivatives was considered to be the reason for the enantioselectivity of the membrane. © 1990, American Chemical Society. All rights reserved.
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页码:2748 / 2752
页数:5
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