SEXUALLY DIMORPHIC EXPRESSION OF THE NGF RECEPTOR GENE IN THE DEVELOPING RAT-BRAIN

被引：37

作者：

KORNACK, DR ^{[1
]}

LU, B ^{[1
]}

BLACK, IB ^{[1
]}

机构：

[1] CORNELL UNIV,MED CTR,COLL MED,DEPT NEUROL,DIV DEV NEUROL,NEW YORK,NY 10021

来源：

BRAIN RESEARCH | 1991年 / 542卷 / 01期

关键词：

HIPPOCAMPUS; BASAL FOREBRAIN; CEREBELLUM; TROPHIC FACTOR; NERVE GROWTH FACTOR; MESSENGER RNA EXPRESSION; SEX DIMORPHISM;

D O I：

10.1016/0006-8993(91)91015-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To define relations between trophic molecules and known sexually dimorphic traits in brain, we examined possible sex differences in nerve growth factor (NGF) and NGF receptor (NGF-R) gene expression in the rat cholinergic basal forebrain (BF)-hippocampal system. Hippocampal NGF mRNA levels did not differ between sexes; in contrast, BF NGF-R mRNA levels were greater in neonatal females than males, paralleling the known dimorphic development of cholinergic enzyme activity. Cerebellar NGF-R mRNA levels were also dimorphic in the neonate, suggesting that sex-specific influences may regulate trophic receptor gene expression in diverse brain systems.

引用

页码：171 / 174

页数：4

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