INDUCTION OF HEME OXYGENASE AS A DEFENSE AGAINST OXIDATIVE STRESS

被引:305
作者
STOCKER, R
机构
[1] The Heart Research Institute, Camperdown, NSW 2050
来源
FREE RADICAL RESEARCH COMMUNICATIONS | 1990年 / 9卷 / 02期
关键词
Antioxidants; Bilirubin; Biliverdin; Haem metabolism; Haem oxygenase; Induction; Oxidative stress; Pro-oxidants;
D O I
10.3109/10715769009148577
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cells respond to metabolic perturbations by producing specific stress proteins. Exposure of mammalian cells to various forms of oxidative stress induces haem oxygenase, the rate-limiting enzyme in haem degradation. This response is proposed to represent an antioxidant defence operating at two different stages simultaneously. It (i) decreases the levels of the potential pro-oxidants haem and haem proteins such as cytochrome P-450 and protoporphyrinogen oxidase, and (ii) increases the tissue concentrations of antio-xidatively active bile pigments. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
引用
收藏
页码:101 / 112
页数:12
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