A NEW CHROMATOGRAPHIC METHOD FOR THE ISOLATION OF (-)-DELTA(9)-(TRANS)-TETRAHYDROCANNABINOLIC ACID-A

被引：25

作者：

LEHMANN, T ^{[1
]}

BRENNEISEN, R ^{[1
]}

机构：

[1] UNIV BERN, INST PHARM, CH-3012 BERN, SWITZERLAND

来源：

PHYTOCHEMICAL ANALYSIS | 1992年 / 3卷 / 02期

关键词：

CANNABIS-SATIVA; (-)-DELTA(9)-TETRAHYDROCANNABINOLIC ACID-A; MEDIUM PRESSURE LIQUID CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; GAS CHROMATOGRAPHY MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

D O I：

10.1002/pca.2800030210

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

(-)-DELTA-9-(trans)-Tetrahydrocannabinolic acid A (THCA-A), which is the main cannabinoid in ripe plants and the biogenetic precursor of the psychoactive (-)-DELTA-9-(trans)-tetrahydrocannabinol, has been isolated from Cannabis sativa L. After extraction with petroleum ether and subsequent fractionation using alkali and diethyl ether, purification was performed by medium pressure liquid chromatography to yield an amorphous > 99% pure powder. THCA-A was characterized by its chromatographic and spectroscopic data.

引用

页码：88 / 90

页数：3

共 13 条

[1] CAPILLARY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY OF VALPROIC ACID METABOLITES IN SERUM AND URINE USING TERT-BUTYLDIMETHYLSILYL DERIVATIVES [J].

ABBOTT, FS ;

KASSAM, J ;

ACHEAMPONG, A ;

FERGUSON, S ;

PANESAR, S ;

BURTON, R ;

FARRELL, K ;

ORR, J .

JOURNAL OF CHROMATOGRAPHY, 1986, 375 (02) :285-298

[2]

BAKER PB, 1980, J ANAL TOXICOL, V4, P145, DOI 10.1093/jat/4.3.145

[3] THE TETRAHYDROCANNABINOL AND TETRAHYDROCANNABINOLIC ACID CONTENT OF CANNABIS PRODUCTS [J].

BAKER, PB ;

TAYLOR, BJ ;

GOUGH, TA .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1981, 33 (06) :369-372

[4]

BRENNEISEN R, 1987, PHARM ACTA HELV, V62, P134

[5]

BRENNEISEN R, 1988, J FORENSIC SCI, V33, P1385

[6]

BRENNEISEN R, 1984, PHARM ACTA HELV, V59, P247

[7]

FARKAS M, 1990, DATA HANDL SCI TECHN, V6, P455, DOI 10.1016/S0922-3487(08)70190-4

[8] TETRAHYDROCANNABINOLCARBOXYLIC ACID A COMPONENT OF HASHISH [J].

KORTE, F ;

HAAG, M ;

CLAUSSEN, U .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1965, 4 (10) :872-&

[9] CARBOXYLATION OF RESORCINOLS WITH METHYLMAGNESIUM CARBONATE . SYNTHESIS OF CANNABINOID ACIDS [J].

MECHOULAM, R ;

BENZVI, Z .

JOURNAL OF THE CHEMICAL SOCIETY D-CHEMICAL COMMUNICATIONS, 1969, (07) :343-+

[10]

MECHOULAM R, 1969, Tetrahedron Letters, V28, P2339

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