INCORPORATION AND RELEASE OF FLUORESCEIN ISOTHIOCYANATE-LINKED DEXTRANS FROM A BEAD-FORMED MACROPOROUS HYDROPHILIC MATRIX WITH POTENTIAL FOR SUSTAINED-RELEASE

被引：12

作者：

ATKINS, TW

MCCALLION, RL

TIGHE, BJ

机构：

[1] ST BARTHOLOMEWS HOSP,DEPT MED ELECTR,LONDON EC1A 7BE,ENGLAND

[2] UNIV ASTON,DEPT CHEM ENGN & APPL CHEM,BIRMINGHAM B4 7ET,W MIDLANDS,ENGLAND

来源：

BIOMATERIALS | 1993年 / 14卷 / 01期

关键词：

FREEZE-THAW POLYMERIZATION; MACROPOROUS BEADS; FITC-DEXTRANS; CONTROLLED RELEASE;

D O I：

10.1016/0142-9612(93)90016-U

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Freeze-thaw polymerization has been used to generate a bead-formed (100-3000 mum) macroporous hydrophilic matrix with potential for the sustained release of macromolecules. While the incorporation of FITC-dextrans marginally increased the equilibrium water content, their in vitro release profiles were characterized by an initial burst followed by a low but sustained release lasting >21 d. The total cumulative release of FD-150 and the percentage of the incorporated FD-150 load subsequently released were reduced compared with FD-20S but for both dextrans these parameters could be enhanced by increasing the bead size and increasing the incubation temperature to 37-degrees-C.

引用

页码：16 / 20

页数：5

共 8 条

[1] SYNTHETIC HYDROGELS .1. HYDROXYALKYL ACRYLATE AND METHACRYLATE COPOLYMERS - WATER BINDING-STUDIES [J].