INCORPORATION AND RELEASE OF FLUORESCEIN ISOTHIOCYANATE-LINKED DEXTRANS FROM A BEAD-FORMED MACROPOROUS HYDROPHILIC MATRIX WITH POTENTIAL FOR SUSTAINED-RELEASE

被引:12
作者
ATKINS, TW
MCCALLION, RL
TIGHE, BJ
机构
[1] ST BARTHOLOMEWS HOSP,DEPT MED ELECTR,LONDON EC1A 7BE,ENGLAND
[2] UNIV ASTON,DEPT CHEM ENGN & APPL CHEM,BIRMINGHAM B4 7ET,W MIDLANDS,ENGLAND
关键词
FREEZE-THAW POLYMERIZATION; MACROPOROUS BEADS; FITC-DEXTRANS; CONTROLLED RELEASE;
D O I
10.1016/0142-9612(93)90016-U
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Freeze-thaw polymerization has been used to generate a bead-formed (100-3000 mum) macroporous hydrophilic matrix with potential for the sustained release of macromolecules. While the incorporation of FITC-dextrans marginally increased the equilibrium water content, their in vitro release profiles were characterized by an initial burst followed by a low but sustained release lasting >21 d. The total cumulative release of FD-150 and the percentage of the incorporated FD-150 load subsequently released were reduced compared with FD-20S but for both dextrans these parameters could be enhanced by increasing the bead size and increasing the incubation temperature to 37-degrees-C.
引用
收藏
页码:16 / 20
页数:5
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