RESOLUTION OF RACEMATES BY DISTILLATION WITH INCLUSION-COMPOUNDS

被引：51

作者：

KAUPP, G

机构：

[1] Organische Chemie I, Universität Oldenburg, D-26111

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1994年 / 33卷 / 07期

关键词：

D O I：

10.1002/anie.199407281

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Will optical resolution by HPLC with chiral columns become obsolete? With a new technique, which should be amenable to upscaling, suspensions of crystalline host compounds such as 1 and 2 in hexane or water form 1:1 complexes with the one enantiomer of a racemic alcohol or ether such as 3 and 4 that fits best into its lattice. The two enantiomers can then be separated by vacuum distillation. (Figure Presented.) Copyright © 1994 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：728 / 729

页数：2

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