INTERLEUKIN-6 PRODUCTION BY BRAIN-TISSUE AND CULTURED ASTROCYTES INFECTED WITH THEILERS MURINE ENCEPHALOMYELITIS VIRUS

被引:20
作者
RUBIO, N
SIERRA, A
机构
[1] Department of Neuroimmunology, Instituto Cajal, Madrid
[2] Unidad de Neuropatologia de Investigacion Experimental, Hospital Principes de España, Barcelona
关键词
D O I
10.1002/glia.440090106
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Theiler's murine encephalomyelitis virus (TMEV) is known to interact with cells of the central nervous system (CNS). Here we report that, interestingly, it is a potent inductor of interleukin-6 (IL-6) in the CNS of infected animals and in pure cultures of astrocytes. Maximal IL-6 gene transcription in glial cells, as detected by bioassay and ELISA, was observed at 6 and 24 h after infection. Astrocytes from both SJL/J and Balb/c (strains of mice susceptible and resistant, respectively, to TMEV-induced demyelination) produced similar amounts of IL-6, measured in tissue culture supernatants. These results indicate that although an immunomodulatory effect can be exercised by IL-6 synthesized by astrocytes, it does not play a crucial role in immune-mediated demyelination induced by TMEV. (C) 1993 Wiley-Liss, Inc.
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页码:41 / 47
页数:7
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