LAMINS AND LAMIN-ASSOCIATED PROTEINS

A variety of morphological and biochemical studies have established that the nuclear lamins play an important role in nuclear structure and dynamics. Recent work reveals the existence of specialized lamin isotypes and novel pathways of modulation of lamin import into the nucleus via phosphorylation by protein kinase C. Other studies also unveil a wide spectrum of molecular interactions between the lamin proteins and integral membrane components of the nuclear envelope.