GASTRIC-ULCERS DIFFER FROM DUODENAL-ULCERS - EVALUATION OF BASAL ACID OUTPUT

被引:9
作者
COLLEN, MJ
SHERIDAN, MJ
机构
[1] LOMA LINDA UNIV,MED CTR,DEPT MED,DIV GASTROENTEROL,LOMA LINDA,CA
[2] INOVA HLTH SYST,INST MED RES,FALLS CHURCH,VA
关键词
GASTRIC ULCER; DUODENAL ULCER; BASAL ACID OUTPUT;
D O I
10.1007/BF01299909
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Patients with pyloric channel and prepyloric gastric ulcers are often considered to have an ulcer diathesis similar to patients with duodenal ulcers, while patients with more proximal gastric ulcers (ie, findus, body, antrum) are excluded. To evaluate possible differences in basal acid outputs with regard to gastric ulcer location, basal acid outputs were determined by nasogastric suction in 80 patients with endoscopically documented benign active gastric ulcers. The results were compared to 65 normal subjects and 155 patients with endoscopically documented duodenal ulcers. There were no significant differences in basal acid outputs among the 80 patients with gastric ulcers with regard to location (ie, fundus-body, antrum, prepyloric, channel), and no significant differences compared to the 65 normal subjects. However basal acid output for the 155 patients with duodenal ulcers was significantly different from the 80 patients with gastric ulcers (P < 0.05) and the 65 normal subjects (P < 0.05). Basal acid outputs tended to be higher and there was more gastric acid hypersecretion when gastric ulcers were located near the pylorus. However, irrespective of gastric ulcer location, basal acid outputs were higher in patients with duodenal ulcers. Seventy-one of the 80 patients with gastric ulcers were treated for eight weeks with standard doses of antisecretory medications, and endoscopic healing or nonhealing was documented. In 60 patients their gastric ulcers completely healed, while 11 patients had nonhealed gastric ulcers. There were no significant differences between the two groups with regard to gender, mean age, or basal acid output. The gastric acid secretory profiles determined in this study do not appear to support the view that prepyloric and pyloric channel gastric ulcers are similar to duodenal ulcers.
引用
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页码:2281 / 2286
页数:6
相关论文
共 44 条
[2]  
Baron JH., 1979, CLIN TESTS GASTRIC S
[3]   RANDOMIZED, DOUBLE-BLIND COMPARISON OF OMEPRAZOLE AND CIMETIDINE IN THE TREATMENT OF SYMPTOMATIC GASTRIC-ULCER [J].
BATE, CM ;
WILKINSON, SP ;
BRADBY, GVH ;
BATESON, MC ;
HISLOP, WS ;
CROWE, JP ;
WILLOUGHBY, CP ;
PEERS, EM ;
RICHARDSON, PDI .
GUT, 1989, 30 (10) :1323-1328
[4]  
BLACKSTONE MO, 1984, ENDOSCOPIC INTERPRET, P87
[5]  
BONNEVIE O, 1975, SCAND J GASTROENTERO, V10, P529
[6]  
BROOKS FP, 1985, DIG DIS SCI S, V30, P15
[7]  
CLASSEN M, 1985, GASTROENTEROLOGY, V88, P1350
[8]  
COCHRAN WG, 1980, STATISTICAL METHODS
[9]   REFRACTORY DUODENAL-ULCERS (NONHEALING DUODENAL-ULCERS WITH STANDARD DOSES OF ANTISECRETORY MEDICATION) [J].
COLLEN, MJ ;
STANCZAK, VJ ;
CIARLEGLIO, CA .
DIGESTIVE DISEASES AND SCIENCES, 1989, 34 (02) :233-237
[10]   DEFINITION FOR IDIOPATHIC GASTRIC-ACID HYPERSECRETION - A STATISTICAL AND FUNCTIONAL-EVALUATION [J].
COLLEN, MJ ;
SHERIDAN, MJ .
DIGESTIVE DISEASES AND SCIENCES, 1991, 36 (10) :1371-1376