HUMAN GASTRIC-INHIBITORY POLYPEPTIDE RECEPTOR - CLONING OF THE GENE (GIPR) AND CDNA

被引：68

作者：

YAMADA, Y ^{[1
]}

HAYAMI, T ^{[1
]}

NAKAMURA, K ^{[1
]}

KAISAKI, PJ ^{[1
]}

SOMEYA, Y ^{[1
]}

WANG, CZ ^{[1
]}

SEINO, S ^{[1
]}

SEINO, Y ^{[1
]}

机构：

[1] CHIBA UNIV,SCH MED,CTR BIOMED SCI,DIV MOLEC MED,CHIBA 280,JAPAN

来源：

GENOMICS | 1995年 / 29卷 / 03期

关键词：

D O I：

10.1006/geno.1995.9937

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Gastric inhibitory polypeptide (GIP), which is released from the gastrointestinal tract, stimulates insulin secretion from pancreatic beta cells and plays a crucial role in the regulation of insulin secretion during the postprandial phase. We have isolated the human gene (GIPR) and cDNA encoding the GIP receptor by a combination of the conventional screening and polymerase chain reaction procedures. Human GIP receptor cDNA encodes a protein of 466 amino acids that is 81.5 and 81.2% identical to the previously cloned hamster and rat GIP receptor, respectively. Hydropathic analysis shows the presence of a signal peptide and seven potential transmembrane domains, a feature characteristic of the VIP/glucagon/secretin receptor family of G protein-coupled receptors. The human GIPR gene is about 13.8 kb long, consists of 14 exons, and carries 17 Alu repeats. (C) 1995 Academic Press, Inc.

引用

页码：773 / 776

页数：4

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