SPECIFIC ANTIBODY-DEPENDENT ACTIVATION OF NEUTROPHILS BY LIPOSOMES CONTAINING SPIN-LABEL LIPID HAPTENS

被引：22

作者：

HAFEMAN, DG

PARCE, JW

MCCONNELL, HM

机构：

[1] Stauffer Laboratory for Physical Chemistry Stanford University, Stanford

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 86卷 / 03期

关键词：

D O I：

10.1016/0006-291X(79)91745-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Superoxide production by human neutrophils can be stimulated by liposomal membranes containing nitroxide spin-labeled lipids in the presence of specific rabbit antibodies [Ab] directed against the nitroxide group. The extent of superoxide production depended strongly on lipid composition under conditions where the concentration of Ab and number of exposed haptens were maintained constant. The dependence of neutrophil activation on the physical properties of the liposomal lipid membrane appears similar to the dependence of complement depletion on these physical properties.

引用

页码：522 / 528

页数：7

共 24 条

[1] BIOLOGICAL DEFENSE MECHANISMS - PRODUCTION BY LEUKOCYTES OF SUPEROXIDE A POTENTIAL BACTERICIDAL AGENT
BABIOR, BM
KIPNES, RS
CURNUTTE, JT
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1973, 52 (03) : 741 - 744
[2] BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77
[3] LATERAL HAPTEN MOBILITY AND IMMUNOCHEMISTRY OF MODEL MEMBRANES
BRULET, P
MCCONNELL, HM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (09) : 2977 - 2981
[4] STRUCTURAL AND DYNAMICAL ASPECTS OF MEMBRANE IMMUNOCHEMISTRY USING MODEL MEMBRANES
BRULET, P
MCCONNELL, HM
[J]. BIOCHEMISTRY, 1977, 16 (06) : 1209 - 1217
[5] BRULET P, 1977, STRUCTURE BIOL MEMBR, P321
[6] CHESON BD, 1976, PROGR CLIN IMMUNOLOG, V2, P1
[7] COMPLEMENT AND IMMUNOGLOBULINS STIMULATE SUPEROXIDE PRODUCTION BY HUMAN LEUKOCYTES INDEPENDENTLY OF PHAGOCYTOSIS
GOLDSTEIN, IM
ROOS, D
KAPLAN, HB
WEISSMANN, G
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1975, 56 (05) : 1155 - 1163
[8] HENKART P, 1977, P NATL ACAD SCI USA, V74, P3537
[9] VISUALIZATION OF SPECIFIC ANTIBODY AND CLQ BINDING TO HAPTEN-SENSITIZED LIPID VESICLES
HENRY, N
PARCE, JW
MCCONNELL, HM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (08) : 3933 - 3937
[10] HUMPHRIES, 1975, P NATN ACAD SCI US, V72, P2483

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