METHODS FOR DRUG DISCOVERY - DEVELOPMENT OF POTENT, SELECTIVE, ORALLY EFFECTIVE CHOLECYSTOKININ ANTAGONISTS

被引:1316
作者
EVANS, BE [1 ]
RITTLE, KE [1 ]
BOCK, MG [1 ]
DIPARDO, RM [1 ]
FREIDINGER, RM [1 ]
WHITTER, WL [1 ]
LUNDELL, GF [1 ]
VEBER, DF [1 ]
ANDERSON, PS [1 ]
CHANG, RSL [1 ]
LOTTI, VJ [1 ]
CERINO, DJ [1 ]
CHEN, TB [1 ]
KLING, PJ [1 ]
KUNKEL, KA [1 ]
SPRINGER, JP [1 ]
HIRSHFIELD, J [1 ]
机构
[1] MERCK INST THERAPEUT RES,RAHWAY,NJ 07065
关键词
D O I
10.1021/jm00120a002
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:2235 / 2246
页数:12
相关论文
共 56 条
  • [1] DIAZEPAM-BINDING INHIBITOR - A NEUROPEPTIDE LOCATED IN SELECTED NEURONAL POPULATIONS OF RAT-BRAIN
    ALHO, H
    COSTA, E
    FERRERO, P
    FUJIMOTO, M
    COSENZAMURPHY, D
    GUIDOTTI, A
    [J]. SCIENCE, 1985, 229 (4709) : 179 - 182
  • [2] THE CHOLECYSTOKININ ANTAGONIST L-364,718 INHIBITS THE ACTION OF CHOLECYSTOKININ BUT NOT BOMBESIN ON RAT PANCREATIC-SECRETION INVIVO
    ANDERSON, L
    DOCKRAY, GJ
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 146 (2-3) : 307 - 311
  • [3] ARIENS EJ, 1979, RECEPTORS COMPREHENS, V1, P33
  • [4] A REARRANGEMENT OF 5-ARYL-1,3-DIHYDRO-2H-1,4-BENZODIAZEPINE-2-14-OXIDES
    BELL, SC
    CHILDRESS, SJ
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1962, 27 (05) : 1691 - &
  • [5] BELL SC, 1964, J HETEROCYCL CHEM, V4, P647
  • [6] BELL SC, 1965, Patent No. 3198789
  • [7] BLOUNT JF, 1983, MOL PHARM, V24, P426
  • [8] AN EXPEDIENT SYNTHESIS OF 3-AMINO-1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE
    BOCK, MG
    DIPARDO, RM
    EVANS, BE
    RITTLE, KE
    VEBER, DF
    FREIDINGER, RM
    [J]. TETRAHEDRON LETTERS, 1987, 28 (09) : 939 - 942
  • [9] SYNTHESIS AND RESOLUTION OF 3-AMINO-1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONES
    BOCK, MG
    DIPARDO, RM
    EVANS, BE
    RITTLE, KE
    VEBER, DF
    FREIDINGER, RM
    HIRSHFIELD, J
    SPRINGER, JP
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (15) : 3232 - 3239
  • [10] BENZODIAZEPINES ANTAGONIZE CHOLECYSTOKININ-INDUCED ACTIVATION OF RAT HIPPOCAMPAL-NEURONS
    BRADWEJN, J
    DEMONTIGNY, C
    [J]. NATURE, 1984, 312 (5992) : 363 - 364