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LIPOSOME ENTRAPPED DESFERRIOXAMINE AND IRON TRANSPORTING IONOPHORES - NEW APPROACH TO IRON CHELATION THERAPY

被引：29
作者：
YOUNG, SP
BAKER, E
HUEHNS, ER
机构：
[1] Department of Clinical Haematology, University College Hospital Medical School, London
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 1979年 / 41卷 / 03期
关键词：
D O I：
10.1111/j.1365-2141.1979.tb05868.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Summary. Liposome‐entrapped desferrioxamine was administered to iron‐overloaded 59Fe labelled mice. When given orally or intraperitoneally entrapment did not enhance the effect of the chelator, but given intravenously liposomal desferrioxamine doubled the 59Fe excretion for a given dose of the drug, and excretion after a single dose continued for up to 3 d. In addition, liposomes containing ionophore A23187 administered concurrently with DTPA caused an excretion of 59Fe, whereas DTPA alone had no effect. Copyright © 1979, Wiley Blackwell. All rights reserved
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页码：357 / 363
页数：7
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