ENZYME-LINKED IMMUNOSORBENT ASSAY OF ANTIGENS FROM CANDIDA-ALBICANS CIRCULATING IN INFECTED MICE AND RABBITS - ROLE OF MANNAN

被引：15

作者：

WARREN, RC ^{[1
]}

RICHARDSON, MD ^{[1
]}

WHITE, LO ^{[1
]}

机构：

[1] SOUTHMEAD GEN HOSP,DEPT MED MICROBIOL,BRISTOL BS10 5NB,ENGLAND

来源：

MYCOPATHOLOGIA | 1979年 / 66卷 / 03期

关键词：

D O I：

10.1007/BF00683968

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Various antisera raised either to antigens of Candida albicans or to sub-lethal infections of blastospores (convalescent sera) were tested for their efficacy in diagnosing systemic disease in artifically infected animals. Globulin from convalescent serum, when conjugated with alkaline phosphatase and used in enzyme-linked immunosorbent assays (ELISA), was the only antiserum type which detected circulating Candida-related antigen in the serum of infected animals. Conjugates made from anti-mannan, anti-blastospore or antimycelial globulin did not detect antigen. Mannan did not appear to be related to an antigen produced in sera of experimentally infected mice. The significance of these results in the diagnosis of systemic candidosis is discussed. © 1979 Kluwer Academic Publishers.

引用

页码：179 / 182

页数：4

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