MONITORING OF BLOOD-GAS PARAMETERS AND ACID-BASE-BALANCE OF PREGNANT AND NONPREGNANT RABBITS (ORYCTOLAGUS-CUNICULUS) IN ROUTINE EXPERIMENTAL CONDITIONS

被引：18

作者：

BARZAGO, MM ^{[1
]}

BORTOLOTTI, A ^{[1
]}

OMARINI, D ^{[1
]}

ARAMAYONA, JJ ^{[1
]}

BONATI, M ^{[1
]}

机构：

[1] UNIV SARAGOSSA,FAC VET,DEPT PHARMACOL,ZARAGOZA,SPAIN

来源：

LABORATORY ANIMALS | 1992年 / 26卷 / 02期

关键词：

BLOOD GAS PARAMETERS; ACID-BASE BALANCE; RABBIT; PREGNANCY;

D O I：

10.1258/002367792780745904

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Blood gas parameters and acid-base balance values were determined in adult pregnant New Zealand rabbits (Oryctolagus cuniculus) in standard laboratory housing conditions and during anaesthesia with an association of ketamine-chlorpromazine, administered before surgical procedures. All the variables were also studied in adult non-pregnant female, used as controls. No differences in pH, sO2c, O2Hb, COHb, sO2m and a-vDO2 were found between pregnant and non-pregnant rabbits in physiological conditions and during anaesthesia. ketamine-chlorpromazine and pregnancy seemed to change the other parameters used to assess the Acid-base balance and the oxygenation conditions. Anaesthesia affected only Hb, O2Ct, O2Cap, CcO2 and P50. The additive effect of pregnancy and anaesthesia modified pCO2, pO2, HCO3-, TCO2, Beb, SBC, BEecf, A-aDO2, RI, MetHb, RHb, CaO2 and CvO2. The patterns described are close to those of other species, suggesting the New Zealand rabbit might be a reliable animal model for monitoring selected variable.

引用

页码：73 / 79

页数：7

共 34 条

[1]

Altman P.L., 1974, BIOL DATA BOOK, P1598

[2]

BARRON DONALD H., 1955, YALE JOUR BIOL AND MED, V28, P197

[3]

BITO LZ, 1969, J PHARMACOL EXP THER, V169, P277

[4] THERMOREGULATORY AND ACUTE-PHASE RESPONSES TO ENDOTOXIN OF FULL-TERM-PREGNANT RABBITS [J].