OLIGONUCLEOTIDE SEQUENCES REQUIRED FOR NATURAL-KILLER-CELL ACTIVATION

被引：104

作者：

KURAMOTO, E

YANO, O

KIMURA, Y

BABA, M

MAKINO, T

YAMAMOTO, S

YAMAMOTO, T

KATAOKA, T

TOKUNAGA, T

机构：

[1] NATL INST HLTH,SHINAGAWA KU,TOKYO 141,JAPAN

[2] MITSUI TOATSU CHEM CO LTD,LIFE SCI RES LABS,MOBARA,CHIBA 297,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1992年 / 83卷 / 11期

关键词：

OLIGONUCLEOTIDE; PALINDROME; NK CELL;

D O I：

10.1111/j.1349-7006.1992.tb02734.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Based on the previous finding that certain 30-mer single-stranded oligodeoxyribonucleotides (oligonucleotides) having particular 6-mer palindromic sequences could induce interferon-alpha and -gamma, and enhance natural killer activity, the present study was carried out to clarify the entire relationship between the activity and the sequence of 30-mer oligonucleotides. The results indicated that the activity depended critically on the presence of particular palindromic sequences including the 5'-CG-3' motif(s). The size and the number of palindromes as well as the extra-palindromic sequences also influenced the activity. An oligonucleotide with a 10-mer palindrome and extra-palindromic oligoguanylate sequences showed the strongest activity among the oligonucleotides tested.

引用

页码：1128 / 1131

页数：4

共 15 条

[1] SELECTION OF SINGLE-STRANDED-DNA MOLECULES THAT BIND AND INHIBIT HUMAN THROMBIN [J].