SHOCK-REINFUSION INJURY TO THE CENTRAL ORGANS AND THE EFFECT OF FREE-RADICAL SCAVENGERS IN THE RAT

被引：16

作者：

HAMANO, K

TSUBOI, H

SEYAMA, A

ESATO, K

机构：

[1] The First Department of Surgery, Yamaguchi University, School of Medicine, Yamaguchi, 755, Ube

来源：

SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY | 1993年 / 23卷 / 10期

关键词：

HEMORRHAGIC SHOCK; FREE RADICAL SCAVENGER; MALONDIALDEHYDE;

D O I：

10.1007/BF00311368

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Hemorrhagic shock-reinfusion injury produces critical changes in various organs with the generation of oxidant-free radicals. Some papers have reported that shock-reinfusion injury to the intestine is effectively reduced by the scavengers of free radicals; however, few reports mention the central organ damage caused by systemic hemorrhagic shock-reinfusion injury. Using a rat systemic hemorrhagic shock model, injury to the central organs, being the brain, heart, lungs, liver, and kidneys was assessed by measuring malondialdehyde (MDA). The MDA levels in the lungs, kidneys, and liver were elevated significantly after reinfusion, although there was no elevation of MDA in the brain or heart. These data show that the lungs, liver, and kidneys are easily damaged by shock-reinfusion, but that the brain and heart are relatively resistant. The efficacy of the free radical scavengers, superoxide dismutase plus catalase and allopurinol, were evaluated 30 min after reinfusion. Pathological examination showed that superoxide dismutase plus catalase and allopurinol reduced reinfusion injury in the lungs, liver, and kidneys. Moreover, superoxide dismutase plus catalase reduced MDA levels in both the liver and kidneys, whereas allopurinol reduced MDA levels only in the kidneys after reinfusion. However, these free radical scavengers could not suppress the elevation of MDA in the lungs after reinfusion.

引用

页码：891 / 896

页数：6

共 21 条

[1]

McCord J.M., Oxygen-derived free radicals in postischemic tissue injury, New Engl J Med, 312, pp. 159-163, (1985)

[2]

Hammond B., Kontos H.A., Hess M.L., Oxygen radicals in the adult respiratory distress syndrome, in myocardial ischemia and reperfusion injury, and in cerebral vascular damage, Can J Physiol Pharmacol, 63, pp. 173-187, (1985)

[3]

Hochstein P., Jain S.K., Association of lipid peroxidation and polymerization of membrane proteins with erythrocyte aging, Fed Proc, 40, pp. 183-188, (1981)

[4]

Tsimoyiannis E.C., Sarros C.J., Tsimoiannis J.C., Moutesidou K., Akalestos G., Kotoulas O.B., Ranitidine and oxygen derived free radical scavengers in haemorragic shock-induced gastric lesions, Gut, 29, pp. 826-829, (1988)

[5]

Itoh M., Guth P.H., Role of oxygen-derived free radicals in hemorragic shock-induced gastric lesions in the rat, Gastroenterology, 88, pp. 1162-1167, (1985)

[6]

Perry M.A., Wadhwa S., Parks D.A., Pickard W., Granger D.N., Role of oxygen radicals in ischemia-induced lesions in the cat stomach, Gastroenterology, 90, pp. 362-367, (1986)

[7]

Gardner T.J., Stewart J.R., Casale A.S., Downey J.M., Chambers D.E., Reduction of myocardial ischemic injury with oxygenderived free radical scavengers, Surgery, 94, pp. 423-427, (1983)

[8]

Otani H., Engelman R.M., Rousou J.A., Breyer R.H., Lemeshow S., Das D.K., Cardiac performance during reperfusion improved by pretreatment with oxygen free-radical scavengers, J Thorac Cardiovasc Surg, 91, pp. 290-295, (1986)

[9]

Przyklenk K., Kloner R.A., Superoxide dismutase plus catalase improve contractile function in the canine model of the “Stunned myocardium”, Circ Res, 58, pp. 148-156, (1986)

[10]

Coles J.C., Ahmed S.N., Mehta H.U., Kauhmann C.E., Role of free radical scavenger in protection of spinal cord during ischemia, Ann Thorac Surg, 41, pp. 551-556, (1986)

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