IMMUNOHISTOCHEMICAL CHARACTERIZATION OF NPY AND SUBSTANCE-P CONTAINING NERVE-TERMINALS IN AGED AND DIABETIC HUMAN SYMPATHETIC-GANGLIA

被引：18

作者：

SCHMIDT, RE

DORSEY, DA

ROTH, KA

机构：

[1] Department of Pathology, Division of Neuropathology, Washington University School of Medicine, Saint Louis, Missouri

来源：

BRAIN RESEARCH | 1992年 / 583卷 / 1-2期

关键词：

DIABETES; NEUROAXONAL DYSTROPHY; NEUROPEPTIDE-Y; SYMPATHETIC AUTONOMIC NEUROPATHY; AGING;

D O I：

10.1016/S0006-8993(10)80043-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To compare the neuropeptide specificity of dystrophic axon formation in aging versus diabetic human sympathetic ganglia we have immunohistochemically characterized neuropeptide Y (NPY) and substance P containing intraganglionic nerve terminals. Prevertebral superior mesenteric but not paravertebral superior cervical ganglia developed markedly swollen NPY containing axonal termini with both aging and diabetes. Substance P containing nerve terminals failed to develop dystrophic changes. Selective loss of classes of nerve terminals may result in discrete functional sequellae.

引用

页码：320 / 326

页数：7

共 19 条

[1] SMALL INTESTINAL MANOMETRY IN HEALTHY ELDERLY SUBJECTS [J].

ANURAS, S ;

SUTHERLAND, J .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1984, 32 (08) :581-583

[2]

BATTLE WM, 1980, GASTROENTEROLOGY, V79, P1217

[3] SOMATOSTATIN IS PRESENT IN A SUBPOPULATION OF NORADRENERGIC NERVE-FIBERS SUPPLYING THE INTESTINE [J].

COSTA, M ;

FURNESS, JB .

NEUROSCIENCE, 1984, 13 (03) :911-919

[4]

DEPONTI F, 1987, P155

[5]

GEBOES K, 1977, Age and Ageing, V6, P197, DOI 10.1093/ageing/6.4.197

[6] DIABETIC AUTONOMIC NEUROPATHY [J].

HOSKING, DJ ;

BENNETT, T ;

HAMPTON, JR .

DIABETES, 1978, 27 (10) :1043-1054

[7]

LINDH B, 1986, J NEUROSCI, V6, P2371

[8] NEUROPEPTIDES AND THE MICROCIRCUITRY OF THE ENTERIC NERVOUS-SYSTEM [J].

LLEWELLYNSMITH, IJ .

EXPERIENTIA, 1987, 43 (07) :813-821

[9] PATTERNS OF ABERRANT SPROUTING IN ALZHEIMERS-DISEASE [J].

MASLIAH, E ;

MALLORY, M ;

HANSEN, L ;

ALFORD, M ;

ALBRIGHT, T ;

DETERESA, R ;

TERRY, R ;

BAUDIER, J ;

SAITOH, T .

NEURON, 1991, 6 (05) :729-739

[10]

MORRIS JL, 1987, J NEUROSCI, V7, P3117

← 1 2 →