THE NICOTINIC ACETYLCHOLINE-RECEPTOR - STRUCTURE AND AUTOIMMUNE PATHOLOGY

被引：144

作者：

CONTITRONCONI, BM

MCLANE, KE

RAFTERY, MA

GRANDO, SA

PROTTI, MP

机构：

[1] UNIV MINNESOTA, SCH MED, DEPT PHARMACOL, MINNEAPOLIS, MN 55455 USA

[2] UNIV MINNESOTA, SCH MED, DEPT MED, MINNEAPOLIS, MN 55455 USA

来源：

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1994年 / 29卷 / 02期

关键词：

LIGAND-GATED ION CHANNELS; NICOTINIC RECEPTOR; IONOTROPIC NEUROTRANSMITTER RECEPTORS; MYASTHENIA GRAVIS;

D O I：

10.3109/10409239409086798

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nicotinic acetylcholine receptors (AChR) are presently the best-characterized neurotransmitter receptors. They are pentamers of homologous or identical subunits, symmetrically arranged to form a transmembrane cation channel. The AChR subunits form a family of homologous proteins, derived from a common ancestor. An autoimmune response to muscle AChR causes the disease myasthenia gravis. This review summarizes recent developments in the understanding of the AChR structure and its molecular recognition by the immune system in myasthenia.

引用

页码：69 / 123

页数：55

共 401 条

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