OPPOSING ACTIONS OF C-ETS PU.1 AND C-MYB PROTOONCOGENE PRODUCTS IN REGULATING THE MACROPHAGE-SPECIFIC PROMOTERS OF THE HUMAN AND MOUSE COLONY-STIMULATING FACTOR-I RECEPTOR (C-FMS) GENES

被引:110
作者
REDDY, MA
YANG, BS
YUE, X
BARNETT, CJK
ROSS, IL
SWEET, MJ
HUME, DA
OSTROWSKI, MC
机构
[1] DUKE UNIV, MED CTR, DEPT MICROBIOL, DURHAM, NC 27710 USA
[2] UNIV QUEENSLAND, CTR MOLEC BIOL & BIOTECHNOL, ST LUCIA, QLD 4072, AUSTRALIA
关键词
D O I
10.1084/jem.180.6.2309
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The receptor for macrophage colony stimulating factor (CSF-1), the c-fms gene product, is a key determinant in the differentiation of monocytic phagocytes. Dissection of the human and mouse c-fms proximal promoters revealed opposing roles for nuclear protooncogenes in the transcriptional regulation of this gene. On the one hand, c-ets-1, c-ets-2, and the macrophage-specific factor PU.1, but not the ets-factor PEA3, trans-activated the c-fms proximal promoter. On the other hand c-myb repressed proximal promoter activity in macrophages and blocked the action of c-ets-1 and c-ets-2. Basal c-fms promoter activity was almost undetectable in the M1 leukaemia line, which expressed high levels of c-myb, but was activated as cells differentiated in response to leukemia inhibitory factor and expressed c-fms mRNA. The repressor function of c-myb depended on the COOH-terminal domain of the protein. We propose that ets-factors are necessary for the tissue-restricted expression of c-fms and that c-myb acts to ensure correct temporal expression of c-fms during myeloid differentiation.
引用
收藏
页码:2309 / 2319
页数:11
相关论文
共 48 条
[1]   VIRAL MYB ONCOGENE ENCODES A SEQUENCE-SPECIFIC DNA-BINDING ACTIVITY [J].
BIEDENKAPP, H ;
BORGMEYER, U ;
SIPPEL, AE ;
KLEMPNAUER, KH .
NATURE, 1988, 335 (6193) :835-837
[2]   ANALYSIS OF THE V-MYB STRUCTURAL COMPONENTS IMPORTANT FOR TRANSACTIVATION OF GENE-EXPRESSION [J].
BORTNER, DM ;
OSTROWSKI, MC .
NUCLEIC ACIDS RESEARCH, 1991, 19 (07) :1533-1539
[3]   SYNERGISTIC ACTIVATION OF THE CHICKEN MIM-1 GENE BY V-MYB AND C/EBP TRANSCRIPTION FACTORS [J].
BURK, O ;
MINK, S ;
RINGWALD, M ;
KLEMPNAUER, KH .
EMBO JOURNAL, 1993, 12 (05) :2027-2038
[4]   CONSTITUTIVE EXPRESSION OF THE UROKINASE PLASMINOGEN-ACTIVATOR GENE IN MURINE RAW264 MACROPHAGES INVOLVES DISTAL AND 5' NONCODING SEQUENCES THAT ARE CONSERVED BETWEEN MOUSE AND PIG [J].
CASSADY, AI ;
STACEY, KJ ;
NIMMO, KA ;
MURPHY, KM ;
VONDERAHE, D ;
PEARSON, D ;
BOTTERI, FM ;
NAGAMINE, Y ;
HUME, DA .
NUCLEIC ACIDS RESEARCH, 1991, 19 (24) :6839-6847
[5]   CONSTITUTIVE EXPRESSION OF A C-MYB CDNA BLOCKS FRIEND MURINE ERYTHROLEUKEMIA CELL-DIFFERENTIATION [J].
CLARKE, MF ;
KUKOWSKALATALLO, JF ;
WESTIN, E ;
SMITH, M ;
PROCHOWNIK, EV .
MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (02) :884-892
[6]   MYB AND ETS PROTEINS COOPERATE IN TRANSCRIPTIONAL ACTIVATION OF THE MIM-1 PROMOTER [J].
DUDEK, H ;
TANTRAVAHI, RV ;
RAO, VN ;
REDDY, ESP ;
REDDY, EP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (04) :1291-1295
[7]   DEVELOPMENTAL REGULATION OF C-MYB IN NORMAL MYELOID PROGENITOR CELLS [J].
DUPREY, SP ;
BOETTIGER, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (20) :6937-6941
[8]   PURIFICATION OF A RAS-RESPONSIVE ADENYLYL CYCLASE COMPLEX FROM SACCHAROMYCES-CEREVISIAE BY USE OF AN EPITOPE ADDITION METHOD [J].
FIELD, J ;
NIKAWA, J ;
BROEK, D ;
MACDONALD, B ;
RODGERS, L ;
WILSON, IA ;
LERNER, RA ;
WIGLER, M .
MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (05) :2159-2165
[9]   EXPRESSION OF MYB, MYC AND FOS PROTO-ONCOGENES DURING THE DIFFERENTIATION OF A MURINE MYELOID-LEUKEMIA [J].
GONDA, TJ ;
METCALF, D .
NATURE, 1984, 310 (5974) :249-251
[10]   THE ACTIVATION DOMAIN OF TRANSCRIPTION FACTOR-PU.1 BINDS THE RETINOBLASTOMA (RB) PROTEIN AND THE TRANSCRIPTION FACTOR-TFIID INVITRO - RB SHOWS SEQUENCE SIMILARITY TO TFIID AND TFIIB [J].
HAGEMEIER, C ;
BANNISTER, AJ ;
COOK, A ;
KOUZARIDES, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (04) :1580-1584