BONE METABOLISM DURING ANTITHYROID DRUG-TREATMENT OF ENDOGENOUS SUBCLINICAL HYPERTHYROIDISM

被引:93
作者
MUDDE, AH [1 ]
HOUBEN, AJHM [1 ]
KRUSEMAN, ACN [1 ]
机构
[1] STATE UNIV LIMBURG HOSP, DEPT INTERNAL MED, DIV ENDOCRINOL, 6201 BX MAASTRICHT, NETHERLANDS
关键词
D O I
10.1111/j.1365-2265.1994.tb02571.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE There is recent evidence that both exogenous and endogenous subclinical thyrotoxicoses are associated with decreased bone mineral density. Scanty information is available on bone metabolism in these conditions when euthyroidism is restored. We evaluated the effect of anti-thyroid drug treatment on bone metabolism in endogenous subclinical hyperthyroidism. DESIGN Prospective follow-up study over 2 years during treatment with methimazole, with an untreated control group. SUBJECTS Sixteen post-menopausal women with endogenous subclinical hyperthyroidism associated with multinodular goitre, eight of whom were treated with methimazole. MEASUREMENTS Serum concentrations of free T4, total T3, TSH, osteocalcin, urinary excretion of hydroxyproline and forearm bone mineral density were measured at regular intervals. RESULTS Significant changes in serum osteocalcin concentration or urinary hydroxyproline excretion were not observed in either group. Distal, but not proximal, forearm bone mineral density, expressed as a percentage of the base-line value, was significantly (P < 0.05) higher in the treated than in the untreated subjects in the second year of treatment. CONCLUSION Treatment with methimazole in postmenopausal women with endogenous subclinical hyperthyroidism associated with multinodular goitre can prevent excessive loss of bone, at least in the distal forearm.
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页码:421 / 424
页数:4
相关论文
共 16 条
[1]   ALKALINE-PHOSPHATASE ISOENZYME PATTERNS IN HYPER-THYROIDISM [J].
COOPER, DS ;
KAPLAN, MM ;
RIDGWAY, EC ;
MALOOF, F ;
DANIELS, GH .
ANNALS OF INTERNAL MEDICINE, 1979, 90 (02) :164-168
[2]   A THERAPEUTIC DILEMMA - SUPPRESSIVE DOSES OF THYROXINE SIGNIFICANTLY REDUCE BONE-MINERAL MEASUREMENTS IN BOTH PREMENOPAUSAL AND POSTMENOPAUSAL WOMEN WITH THYROID-CARCINOMA [J].
DIAMOND, T ;
NERY, L ;
HALES, I .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 72 (06) :1184-1188
[3]   BONE GLA PROTEIN AND SEX HORMONE-BINDING GLOBULIN IN NONTOXIC GOITER - PARAMETERS FOR METABOLIC STATUS AT THE TISSUE-LEVEL [J].
FABER, J ;
PERRILD, H ;
JOHANSEN, JS .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1990, 70 (01) :49-55
[4]   SERUM BONE GLA PROTEIN (BGP) DURING TREATMENT OF HYPERTHYROIDISM AND HYPOTHYROIDISM - A LONGITUDINAL-STUDY [J].
FABER, J ;
PERRILD, H ;
JOHANSEN, JS .
HORMONE AND METABOLIC RESEARCH, 1991, 23 (03) :135-138
[5]  
FOKLES J, 1991, CLIN ENDOCRINOL, V39, P521
[6]   SERUM BONE GLA PROTEIN - A MARKER OF BONE TURNOVER IN HYPERTHYROIDISM [J].
GARREL, DR ;
DELMAS, PD ;
MALAVAL, L ;
TOURNIAIRE, J .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1986, 62 (05) :1052-1055
[7]   MORBIDITY IN PATIENTS ON L-THYROXINE - A COMPARISON OF THOSE WITH A NORMAL TSH TO THOSE WITH A SUPPRESSED TSH [J].
LEESE, GP ;
JUNG, RT ;
GUTHRIE, C ;
WAUGH, N ;
BROWNING, MCK .
CLINICAL ENDOCRINOLOGY, 1992, 37 (06) :500-503
[8]   DETERMINATION OF BONE-MINERAL DENSITY BY QUANTITATIVE COMPUTED-TOMOGRAPHY AND SINGLE PHOTON-ABSORPTIOMETRY IN SUBCLINICAL HYPERTHYROIDISM - A RISK OF EARLY OSTEOPENIA IN POSTMENOPAUSAL WOMEN [J].
LEHMKE, J ;
BOGNER, U ;
FELSENBERG, D ;
PETERS, H ;
SCHLEUSENER, H .
CLINICAL ENDOCRINOLOGY, 1992, 36 (05) :511-517
[9]   THE EARLY EFFECTS OF RADIOIODINE THERAPY FOR HYPERTHYROIDISM ON BIOCHEMICAL INDEXES OF BONE TURNOVER [J].
MACLEOD, JM ;
MCHARDY, KC ;
HARVEY, RD ;
DUNCAN, A ;
REID, IW ;
BEWSHER, PD ;
ROBINS, SP .
CLINICAL ENDOCRINOLOGY, 1993, 38 (01) :49-53
[10]   INTERINDIVIDUAL DIFFERENCES IN THE PITUITARY-THYROID AXIS INFLUENCE THE INTERPRETATION OF THYROID-FUNCTION TESTS [J].
MEIER, CA ;
MAISEY, MN ;
LOWRY, A ;
MULLER, J ;
SMITH, MA .
CLINICAL ENDOCRINOLOGY, 1993, 39 (01) :101-107