EVIDENCE FOR THE PRODUCTION AND ACTION OF INTERLEUKIN-10 IN PITUITARY-CELLS

被引：28

作者：

HUGHES, TK ^{[1
]}

CADET, P ^{[1
]}

RADY, PL ^{[1
]}

TYRING, SK ^{[1
]}

CHIN, R ^{[1
]}

SMITH, EM ^{[1
]}

机构：

[1] UNIV TEXAS,MED BRANCH,DEPT PSYCHIAT & BEHAV SCI,GALVESTON,TX 77550

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 1994年 / 14卷 / 01期

关键词：

NEUROIMMUNOMODULATION; IMMUNE SYSTEM; PITUITARY; INTERLEUKIN-10; CORTICOTROPIN;

D O I：

10.1007/BF02088589

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

1. Interleukin-10 (IL-10) has a wide range of activities in the immune system such as modulation of interferon-gamma (IFN-gamma) and antibody production. The neuropeptide hormone corticotropin (ACTH) has similar activities, suggesting that a bidirectional communication mechanism operates between the immune and the neuroendocrine system involving these two substances. 2. Murine pituitary tumor cells (AtT-20) were found to produce up to 3 ng/ml of IL-10. 3. Pituitary cell corticotropin production was enhanced by IL-10 treatment. 4. IL-10 induced the production of ACTH in mouse splenocytes. 5. Authenticity of pituitary-derived IL-10 was shown by the demonstration of identical neucleic acid sequences of reverse-transcribed, polymerase chain reaction amplified fragments of cDNA obtained from murine splenocytes, a murine pituitary tumor cell line, and freshly isolated murine pituitaries.

引用

页码：59 / 69

页数：11

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