A SOLID-PHASE PROTOCOL OF THE BIGINELLI DIHYDROPYRIMIDINE SYNTHESIS SUITABLE FOR COMBINATORIAL CHEMISTRY

被引：304

作者：

WIPF, P

CUNNINGHAM, A

机构：

[1] Department of Chemistry, University of Pittsburgh, Pittsburgh

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 43期

关键词：

D O I：

10.1016/0040-4039(95)01660-A

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new protocol for solid phase Biginelli condensations of beta-ketoesters, aldehydes and ureas has been developed. This method uses a Wang resin-linked GABA urea and provides dihydropyrimidines in a single operation in high yield and purity suitable for subsequent direct solution phase screening.

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页码：7819 / 7822

页数：4

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