SOMATIC MUTATIONS IN THE BRAIN - RELATIONSHIP TO AGING

被引：34

作者：

EVANS, DAP ^{[1
]}

BURBACH, JPH ^{[1
]}

VANLEEUWEN, FW ^{[1
]}

机构：

[1] UNIV UTRECHT, RUDOLF MAGNUS INST NEUROSCI,DEPT MED PHARMACOL, 3584 CG UTRECHT, NETHERLANDS

来源：

MUTATION RESEARCH-DNAGING GENETIC INSTABILITY AND AGING | 1995年 / 338卷 / 1-6期

关键词：

BRAIN; NEURON; SOMATIC MUTATION; RECOMBINATION; DNA DAMAGE; DNA REPAIR; VASOPRESSIN;

D O I：

10.1016/0921-8734(95)00022-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic instability is generally thought to underlie the process of aging and is predominantly associated with meiosis and mitosis. This review will discuss DNA damage and repair, somatic mutations and somatic recombination events in non-dividing neurons in relation to aging. In general it can be concluded that mutagenesis operates at high frequency in the brain. Present data do not provide clear evidence for accumulating DNA damage or a change in DNA repair activity in the brain with age. However, a linear age-related increase in frameshift mutations has been shown to occur in vasopressin neurons of the rat, revealing a novel post-mitotic mechanism.

引用

页码：173 / 182

页数：10

共 47 条

[1] ON SOMATIC RECOMBINATION IN THE CENTRAL-NERVOUS-SYSTEM OF TRANSGENIC MICE
ABELIOVICH, A
GERBER, D
TANAKA, O
KATSUKI, M
GRAYBIEL, AM
TONEGAWA, S
[J]. SCIENCE, 1992, 257 (5068) : 404 - 408
[2] ALT F W, 1991, Current Biology, V1, P3, DOI 10.1016/0960-9822(91)90108-9
[3] DEVELOPMENT OF DIENCEPHALON IN RAT .1. AUTORADIOGRAPHIC STUDY OF TIME OF ORIGIN AND SETTLING PATTERNS OF NEURONS OF HYPOTHALAMUS
ALTMAN, J
BAYER, SA
[J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1978, 182 (04) : 945 - 971
[4] Bernstein C., 1991, AGING SEX DNA REPAIR
[5] RECOMBINATION BETWEEN IMMUNOGLOBULIN VARIABLE REGION GENE SEGMENTS IS ENHANCED BY TRANSCRIPTION
BLACKWELL, TK
MOORE, MW
YANCOPOULOS, GD
SUH, H
LUTZKER, S
SELSING, E
ALT, FW
[J]. NATURE, 1986, 324 (6097) : 585 - 589
[6] BURBACH JPH, 1984, NEUROENDOCRINOLOGY, V39, P582
[7] THE RECOMBINATION ACTIVATING GENE-1 (RAG-1) TRANSCRIPT IS PRESENT IN THE MURINE CENTRAL-NERVOUS-SYSTEM
CHUN, JJM
SCHATZ, DG
OETTINGER, MA
JAENISCH, R
BALTIMORE, D
[J]. CELL, 1991, 64 (01) : 189 - 200
[8] FRAMESHIFT MUTATIONS AT 2 HOTSPOTS IN VASOPRESSIN TRANSCRIPTS IN POSTMITOTIC NEURONS
EVANS, DAP
VANDERKLEIJ, AAM
SONNEMANS, MAF
BURBACH, JPH
VANLEEUWEN, FW
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (13) : 6059 - 6063
[9] EVANS MK, 1993, J BIOL CHEM, V268, P4839
[10] TRANSGENIC MICE AS MODEL SYSTEMS FOR STUDYING GENE-MUTATIONS INVIVO
GOSSEN, J
VIJG, J
[J]. TRENDS IN GENETICS, 1993, 9 (01) : 27 - 31

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