SYNTHESIS AND ADRENOCORTICAL INHIBITING ACTIVITY OF SUBSTITUTED DIPHENYLALKYLAMINES

被引：11

作者：

BLANK, B

ZUCCARELLO, WA

COHEN, SR

FRISHMUTH, GJ

SCARICACIOTTOLI, D

机构：

[1] Research and Development Division, Smith Kline & French Laboratories, Philadelphia, Pennsylvania

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 02期

关键词：

D O I：

10.1021/jm00302a016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A number of diphenylpropylamines and diphenylbutylamines with and without branched side chains were prepared as specific inhibitors of aldosterone biosynthesis. The adrenal corticosteroid inhibiting activity of the compounds was measured in one or more bioassay systems. Many of the compounds were found to be moderately potent, specific inhibitors of aldosterone biosynthesis. © 1969, American Chemical Society. All rights reserved.

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页码：271 / +

页数：1

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