INFANTILE NEURONAL CEROID-LIPOFUSCINOSIS IS NOT AN ALLELIC FORM OF BATTEN DISEASE - EXCLUSION OF CHROMOSOME-16 REGION WITH LINKAGE ANALYSES

被引：9

作者：

JOKIAHO, I

PUHAKKA, L

SANTAVUORI, P

MANNINEN, T

NYMAN, K

PELTONEN, L

机构：

[1] UNIV HELSINKI,DEPT CHILD NEUROL,SF-00290 HELSINKI 29,FINLAND

[2] UNIV HELSINKI,DEPT OPHTHALMOL,SF-00290 HELSINKI 29,FINLAND

来源：

GENOMICS | 1990年 / 8卷 / 02期

关键词：

D O I：

10.1016/0888-7543(90)90298-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Infantile neuronal ceroid-lipofuscinosis (CLN1) is the form of neuronal ceroid-lipofuscinoses (NCL) with the earliest onset of symptoms. The locus of the most common form of these disorders, juvenile NCL (CLN3), has been mapped to chromosome 16. We report here linkage data of the same region in Finnish CLN1 families. Our results indicate that CLN1 is not allelic with CLN3 but represents a different locus, which is not located within about 70 cM in chromosome 16. © 1990.

引用

页码：391 / 393

页数：3

共 14 条

[1]

EIBERG H, 1989, CLIN GENET, V36, P217

[2] BATTEN DISEASE (SPIELMEYER-VOGT DISEASE, JUVENILE ONSET NEURONAL CEROID-LIPOFUSCINOSIS) GENE (CLN3) MAPS TO HUMAN CHROMOSOME-16 [J].