EXPRESSION OF CR-1 (CD35) MESSENGER-RNA IN PODOCYTES FROM ADULT AND FETAL HUMAN KIDNEYS

被引：36

作者：

APPAY, MD ^{[1
]}

KAZATCHKINE, MD ^{[1
]}

LEVISTRAUSS, M ^{[1
]}

HINGLAIS, N ^{[1
]}

BARIETY, J ^{[1
]}

机构：

[1] INST PASTEUR,INSERM,U276,F-75724 PARIS 15,FRANCE

来源：

KIDNEY INTERNATIONAL | 1990年 / 38卷 / 02期

关键词：

D O I：

10.1038/ki.1990.198

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The presence of CR1 mRNA in podocytes was investigated using a 35S-labeled CR1 cDNA probe and in situ hybridization in section from fetal and adult human kidneys. CR1 mRNA was only detected in immature podocytes at early stages of glomerular differentiation in the fetal kidney. In contrast, CR1 antigen was abundantly expressed on immature and mature podocytes in fetal kidneys and adult glomeruli. Thus, the expression of the CR1 gene in podocytes is tightly regulated. It is possible that the prolonged life span of adult podocytes is associated with a slow turnover of CR1 and low or intermittent accumulation of CR1 mRNA transcripts.

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页码：289 / 293

页数：5

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