CONTROL OF EXPERIMENTAL AUTOIMMUNE UVEORETINITIS BY LOW-DOSE T-CELL VACCINATION

被引：22

作者：

BERAUD, E ^{[1
]}

KOTAKE, S ^{[1
]}

CASPI, RR ^{[1
]}

ODDO, SM ^{[1
]}

CHAN, CC ^{[1
]}

GERY, I ^{[1
]}

NUSSENBLATT, RB ^{[1
]}

机构：

[1] NEI,IMMUNOL LAB,BETHESDA,MD 20892

来源：

CELLULAR IMMUNOLOGY | 1992年 / 140卷 / 01期

关键词：

D O I：

10.1016/0008-8749(92)90180-W

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autoimmune T lymphocytes can be used under appropriate conditions to induce resistance to the specific autoimmune disease that they usually produce. This practice, termed T cell vaccination, was found to be effective with the injection of a low (subpathogenic) number of autoaggressive T line lymphocytes. We report here that T cell vaccination produced marked resistance to the expression of experimental autoimmune uveoretinitis (EAU) in Lewis rats. In addition, vaccination led to the appearance of lymphoid cells in the vaccinated rats that demonstrated proliferative responses against idiotypic and ergotypic specificities of the injected T cells. This is the first report demonstrating that effector T lymphocytes specific for ocular antigens may be used as agents to modulate immunopathogenic responses responsible for EAU. © 1992.

引用

页码：112 / 122

页数：11

共 36 条

[1]

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[2] VACCINATION AGAINST AUTOIMMUNE ENCEPHALOMYELITIS WITH LYMPHOCYTE-T LINE CELLS REACTIVE AGAINST MYELIN BASIC-PROTEIN [J].