THE RELEASE OF NEURONAL 5-HT FROM THE INTESTINE OF A TELEOST FISH, PLATYCEPHALUS-BASSENSIS

被引：9

作者：

ANDERSON, CR ^{[1
]}

CAMPBELL, G ^{[1
]}

OSHEA, F ^{[1
]}

PAYNE, M ^{[1
]}

机构：

[1] UNIV MELBOURNE,DEPT ZOOL,PARKVILLE,VIC 3052,AUSTRALIA

来源：

JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM | 1991年 / 33卷 / 03期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

SEROTONIN; ENTERIC NERVOUS SYSTEM; FLUOXETINE; TETRODOTOXIN; RESERPINE;

D O I：

10.1016/0165-1838(91)90024-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The superfused, isolated intestine of a teleost fish which lacks enterochromaffin cells spontaneously released 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA), presumably from enteric neurons. The release of 5-HT, but not 5-HIAA, increased on transmural electrical stimulation. Addition of tetrodotoxin or omission of Ca2+ from the superfusate prevented the increase in 5-HT release on electrical stimulation. Fluoxetine added to the superfusate increased the amount of 5-HT released spontaneously but also prevented the increase in 5-HT release on stimulation. Pretreatment of fish with reserpine markedly reduced tissue levels of 5-HT and 5-HIAA and led to an almost complete loss of the spontaneous release of 5-HT and an elimination of the stimulated release of 5-HT.

引用

页码：239 / 246

页数：8

共 24 条

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