DIFFERENTIAL SUBCELLULAR-DISTRIBUTION OF PC1, PC2 AND FURIN IN BOVINE ADRENAL-MEDULLA AND SECRETION OF PC1 AND PC2 FROM THIS TISSUE

被引：31

作者：

KIRCHMAIR, R

EGGER, C

GEE, P

HOGUEANGELETTI, R

FISCHERCOLBRIE, R

LASLOP, A

WINKLER, H

机构：

[1] UNIV INNSBRUCK,DEPT PHARMACOL,PETER MAYR STR 1A,A-6020 INNSBRUCK,AUSTRIA

[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT BIOL & CANC,BRONX,NY 10461

来源：

NEUROSCIENCE LETTERS | 1992年 / 143卷 / 1-2期

关键词：

ENDOPEPTIDASE; SECRETION; CHROMAFFIN GRANULE;

D O I：

10.1016/0304-3940(92)90252-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The subcellular distribution of PC1, PC2 and furin was determined in bovine adrenal medulla by immunoblotting of fractions obtained by density gradient centrifugation. PC1 and PC2 were found to be confined to chromaffin granules whereas furin (C-terminal-peptide) was absent from these organelles. Stimulation of bovine adrenal medulla by carbamoylcholine chloride induced the secretion of PC1 and PC2. The secreted enzymes had the same molecular size as PC1 and PC2 present in chromaffin granules.

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页码：143 / 145

页数：3

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