A SIMPLE, EFFICIENT, 2-STEP SYNTHESIS OF SYMMETRICAL 2,7-DIALKYL-1,6-DIOXASPIRO[4.4]NONANES

被引：12

作者：

BALLINI, R

BOSICA, G

USELLI, A

机构：

[1] Dipartimento di Scienze Chimiche, università Camerino

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1994年 / 31卷 / 01期

关键词：

D O I：

10.1002/jhet.5570310145

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A two-step synthesis of symmetric 2,7-dialkyl-1,6-dioxaspiro[4.4]nonanes has been achieved by double Michael addition of nitromethane with two moles of enones on Amberlyst A21, followed by in situ reduction with sodium borohydride, then spontaneous spiroketalization of the obtained nitrodiol, by the Nef reaction under acidic conditions, affords the title compounds in good yields.

引用

页码：259 / 260

页数：2

共 12 条

[1] HYDROXY-FUNCTIONALIZED CONJUGATED NITROOLEFINS AS IMMEDIATE PRECURSORS OF SPIROKETALS - A NEW SYNTHESIS OF 1,7-DIOXASPIRO[5.5]UNDECANE AND (E)-2-METHYL-1,7-DIOXASPIRO[5.6]DODECANE [J].