ACTIVITY OF CLARITHROMYCIN AGAINST INTRACELLULAR MYCOBACTERIUM-PARATUBERCULOSIS - PUTATIVE AGENT OF CROHNS-DISEASE

被引：7

作者：

MARKESICH, DC ^{[1
]}

ELZAATARI, FAK ^{[1
]}

GRAHAM, DY ^{[1
]}

机构：

[1] VET AFFAIRS MED CTR 111D,INFLAMMATORY BOWEL DIS LAB,2002 HOLCOMBE BLVD,HOUSTON,TX 77030

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 1993年 / 5卷 / 08期

关键词：

MYCOBACTERIUM-PARATUBERCULOSIS; CROHNS DISEASE; SUSCEPTIBILITY; CLARITHROMYCIN; MYCOBACTERIA;

D O I：

10.1097/00042737-199308000-00010

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objective: To test whether Mycobacterium paratuberculosis, the putative etiologic agent of Crohn's disease, was senisitive to clarithromycin. Design: To test the susceptibility of two mycobactin-dependent mycobacteria, M. paratuberculosis and M. avium subsp. silvaticum, to clarithromycin grown in mouse monocyte/macrophage cell line J774A.1. Results: Clarithromycin, 2 and 4 mug/ml, inhibited M. paratuberculosis (80 and 25% of control, respectively) but was less effective against M. avium subsp. silvaticum (80 and 82% of control, respectively) growing intracellularly in the murine macrophage cell line J-774A.1. Conclusions: Clarithromycin shows promise for use in double-blind controlled trials for testing the hypothesis that M. paratuberculosis is etiologically related to Crohn's disease.

引用

页码：613 / 615

页数：3

共 27 条

[1] Dalziels T.K., Chronic intestinal enteritis, BMJ, 2, pp. 1068-1070, (1913)
[2] Chiodini R.I., Van Kruiningen H.J., Thayer W.R., Merkal R.S., Coutu J.A., Possible role of mycobacteria in inflammatory bowel disease. I. An unclassified Mycobacterium species isolated from patients with Crohn’s disease, Dig Dis Sci, 29, pp. 1073-1079, (1984)
[3] Gitnick G., Collins J., Beaman B., Brooks O., Arthur M., Imaeda T., Et al., Preliminary report on isolation of mycobacteria from patients with Crohn’s disease, Dig Dis Sci, 34, pp. 925-932, (1989)
[4] Graham D.V., Markesich D.C., Yoshimura H.H., Mycobacteria and inflammatory bowel disease. Results of culture, Gastroenterology, 92, pp. 436-442, (1987)
[5] Haagsma J., Mulder C., Eger A., Bruins J., Ketel R.J., Tytgat G., Mycobacterium species isolated from patients with Crohn’s disease, Inflammatory Bowel Disease: Current Status and Future Research, pp. 535-537, (1982)
[6] Graham D.Y., Markesich D.C., Yoshlmura H.H., Estes M.K., Microbial aetiology of Crohn’s disease: Mycobacteria — cause or commensal?, Inflammatory Bowel Disease, pp. 179-200, (1991)
[7] Chiodini R.J., Crohn’s disease and the mycobacterioses: A review and comparison of two disease entities, Clin Microbiol Rev, 2, pp. 90-117, (1989)
[8] Sanderson J.D., Moss M.T., Tizard M.L., Hermon-Taylor J., Mycobacterium paratuberculosis, Gut, 33, pp. 890-896, (1992)
[9] Moss M.T., Sanderson J.D., Tizard M., Hermon-Taylor J., El-Zaatari F., Markesich D.C., Et al., Polymerase chain reaction detection of Mycobacterium paratuberculosis and Mycobacterium avium subsp. Silvaticum in long-term cultures of Crohn’s disease and control tissues, Gut, 33, pp. 1209-1213, (1992)
[10] Frenandes P.B., Hardy D.J., McDaniel D., Hanson C.W., Swanson R.N., In vitro, Antimicrob Agents Chemother, 33, pp. 1531-1534, (1989)

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