NEUROPEPTIDES AND INTERLEUKIN-6 IN HUMAN JOINT INFLAMMATION - RELATIONSHIP BETWEEN INTRAARTICULAR SUBSTANCE-P AND INTERLEUKIN-6 CONCENTRATIONS

被引：55

作者：

ARNALICH, F

DEMIGUEL, E

PEREZAYALA, C

MARTINEZ, M

VAZQUEZ, JJ

GIJONBANOS, J

HERNANZ, A

机构：

[1] UNIV AUTONOMA MADRID, HOSP LA PAZ, DEPT MED, DIV INTERNAL MED, MADRID, SPAIN

[2] AUTONOMOUS UNIV MADRID, HOSP LA PAZ, DIV BIOCHEM, MADRID, SPAIN

来源：

NEUROSCIENCE LETTERS | 1994年 / 170卷 / 02期

关键词：

SUBSTANCE P; CALCITONIN GENE-RELATED PEPTIDE; VIP; INTERLEUKIN-6; SYNOVIAL FLUID; RHEUMATOID ARTHRITIS; OSTEOARTHRITIS;

D O I：

10.1016/0304-3940(94)90331-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Plasma and synovial fluid concentrations of interleukin-6 (IL-6), using an enzyme-linked immunosorbent assay, as well as immunoreactive levels of calcitonin gene-related peptide (CGRP), substance P and vasoactive intestinal peptide (VIP) were measured in 18 patients with rheumatoid arthritis and 20 with osteoarthritis of the knee. The concentrations of IL-6 were elevated in both plasma and synovial fluids from patients with rheumatoid arthritis whereas higher levels of substance P-, CGRP- and VIP-like immunoreactivities were found in the synovial fluid, but not in plasma, from patients with rheumatoid arthritis when compared with those in osteoarthritis. Furthermore, IL-6 and substance P levels in synovial fluid were significantly correlated both in rheumatoid arthritis and osteoarthritis patients. Our data seem to support the idea of an important role shared by neuropeptides and IL-6 in the pathogenesis of human inflammatory joint disease.

引用

页码：251 / 254

页数：4

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