POROUS GRAPHITIZED CARBON AND OCTADECYLSILICA COLUMNS IN THE SEPARATION OF SOME MONOAMINE-OXIDASE INHIBITORY DRUGS

The retentions of seventeen monoamine oxidase inhibitory drugs (propargylamine derivatives) were determined on a porous graphitized carbon (PGC) column using unbuffered methanol-water and acetonitrile-water eluents and on an octadecylsilica column with methanol-water eluents using constant and varying buffer concentrations. Principal component analysis showed that the retention characteristics of the PGC and octadecylsilica columns differ considerably. A marked deviation between the selectivities of methanol and acetonitrile organic modifiers was observed on PGC. The buffer concentration has a significant impact on the retention of drugs on the octadecylsilica column. The type of substitution (heterocyclic, condensed ring, substituted benzene) accounts for the retention differences irrespective of the type of column, eluent and buffer concentration.