PRODUCTION OF INTERFERONS AND LYMPHOKINES IN LEUKOCYTE-CULTURES OF PATIENTS WITH SCHIZOPHRENIA

被引:66
作者
HORNBERG, M
AROLT, V
WILKE, I
KRUSE, A
KIRCHNER, H
机构
[1] UNIV LUBECK,SCH MED,INST IMMUNOL & TRANSFUS MED,D-23538 LUBECK,GERMANY
[2] UNIV LUBECK,SCH MED,DEPT PSYCHIAT,D-23538 LUBECK,GERMANY
关键词
LYMPHOKINE PRODUCTION; SERUM SIL-2R; (SCHIZOPHRENIA);
D O I
10.1016/0920-9964(94)00046-B
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Recently, several lines of evidence have suggested the possibility of immunological dysfunction in the pathogenesis of schizophrenia. We therefore investigated the ability to produce interferons and lymphokines in response to mitogenic or viral stimulation in a whole blood assay of 37 schizophrenic patients (DSM-III-R) and of 42 healthy blood donors. Phytohaemagglutinin (PHA) was used for the induction of interleukin-2 (IL-2), interferon gamma (IFN gamma), interleukin-6 (IL-6) and the soluble interleukin-2 receptor (sIL-2R) and Newcastle Disease Virus (NDV) for the induction of interferon alpha(2) (IFN alpha(2)). All lymphokines and, in addition, the sIL-2R in the sera were determined by ELISA technique. The psychopathological status of the patients was assessed by psychiatrists according to internationally accepted standards. The patient group showed a trend to lower levels of the interferons alpha(2) and gamma and a significant decrease of IL-2 production. The sIL-2R levels were significantly increased in the sera of schizophrenic patients. The latter increase was associated with a poor assessment of prognosis (Strauss and Carpenter). This association appears to be of interest. However, its significance is not understood, since longitudinal studies could not be performed.
引用
收藏
页码:237 / 242
页数:6
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