EFFECT OF ANTIMICROBIAL AND ANTINEOPLASTIC DRUGS ON THE UPTAKE OF FLUCONAZOLE BY HUMAN NEUTROPHILS AND TISSUE-CULTURE CELLS

被引：1

作者：

GARCIA, I ^{[1
]}

PASCUAL, A ^{[1
]}

CONEJO, C ^{[1
]}

SALVADOR, J ^{[1
]}

PEREA, EJ ^{[1
]}

机构：

[1] UNIV SEVILLE,SCH MED,DEPT MICROBIOL,E-41080 SEVILLE,SPAIN

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 1993年 / 12卷 / 12期

关键词：

D O I：

10.1007/BF01992170

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The effect of eight antimicrobial and three antineoplastic drugs on the uptake of fluconazole by human neutrophils and culture epithelial cells was evaluated. Fluconazole reached higher concentrations intracellularly than extracellularly (cellular to extracellular concentration ratio C/E greater than or equal to 1.3) in the presence of therapeutical concentrations of the antimicrobial and antineoplastic agents evaluated.

引用

页码：944 / 947

页数：4

共 12 条

[1] FUNGAL-INFECTIONS IN CANCER-PATIENTS - AN INTERNATIONAL AUTOPSY SURVEY [J].

BODEY, G ;

BUELTMANN, B ;

DUGUID, W ;

GIBBS, D ;

HANAK, H ;

HOTCHI, M ;

MALL, G ;

MARTINO, P ;

MEUNIER, F ;

MILLIKEN, S ;

NAOE, S ;

OKUDAIRA, M ;

SCEVOLA, D ;

VANTWOUT, J .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1992, 11 (02) :99-109

[2] QUANTITATIVE RELATIONSHIPS BETWEEN CIRCULATING LEUKOCYTES AND INFECTION IN PATIENTS WITH ACUTE LEUKEMIA [J].

BODEY, GP ;

BUCKLEY, M ;

SATHE, YS ;

FREIREICH, EJ .

ANNALS OF INTERNAL MEDICINE, 1966, 64 (02) :328-+

[3]

BODEY GP, 1982, SEMIN HEMATOL, V19, P193

[4]

KLEMPNER MS, 1981, J INFECT DIS, V136, P502

[5]

LAZAR JD, 1990, REV INFECT DIS S3, V12, P327

[6] BACTEREMIAS AND FUNGEMIAS IN ONCOLOGIC PATIENTS WITH CENTRAL VENOUS CATHETERS - CHANGING SPECTRUM OF INFECTION [J].

LOWDER, JN ;

LAZARUS, HM ;

HERZIG, RH .

ARCHIVES OF INTERNAL MEDICINE, 1982, 142 (08) :1456-1459

[7]

MANDELL LA, 1982, REV INFECT DIS, V4, P683

[8] EFFECT OF ANTIMICROBIAL AND ANTINEOPLASTIC DRUGS ALONE AND IN COMBINATION ON THE PHAGOCYTIC AND CANDIDACIDAL FUNCTION OF HUMAN POLYMORPHONUCLEAR LEUKOCYTES [J].

PALLISTER, CJ ;

WARNOCK, DW .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1989, 23 (01) :87-94

[9] FLUOROMETRIC MEASUREMENT OF OFLOXACIN UPTAKE BY HUMAN POLYMORPHONUCLEAR LEUKOCYTES [J].

PASCUAL, A ;

GARCIA, I ;

PEREA, EJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (05) :653-656

[10] UPTAKE AND INTRACELLULAR ACTIVITY OF FLUCONAZOLE IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES [J].

PASCUAL, A ;

GARCIA, I ;

CONEJO, C ;

PEREA, EJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (02) :187-190

← 1 2 →