TREATMENT OF DENERVATION DISUSE OSTEOPOROSIS IN THE RAT WITH A CAPACITIVELY COUPLED ELECTRICAL SIGNAL - EFFECTS ON BONE-FORMATION AND BONE-RESORPTION

Utilizing a sciatic neurectomy model of disuse osteoporosis, the effects on rates of bone formation and bone resorption were examined when a capacitively coupled electrical signal was applied to the denervated tibia in the rat. A low-voltage, symmetrical sine wave, 60-kHz, capacitively coupled signal had no significant effect on the amount of bone resorption occurring in denervated right tibiae in rats previously labeled with [3H]tetracycline. If a similar capacitively coupled signal was applied to rats in which osteoporosis was well established, and the rats were labeled with [3H]tetracycline daily during a 12-day treatment period, it was found that there was statistically significant enhancement of the amount of new bone formation, in the tibiae that received the signal as compared with that of the controls. Additional study results are discussed.