ROTAVIRAL IMMUNITY IN GNOTOBIOTIC CALVES - HETEROLOGOUS RESISTANCE TO HUMAN-VIRUS INDUCED BY BOVINE VIRUS

被引：105

作者：

WYATT, RG ^{[1
]}

MEBUS, CA ^{[1
]}

YOLKEN, RH ^{[1
]}

KALICA, AR ^{[1
]}

JAMES, HD ^{[1
]}

KAPIKIAN, AZ ^{[1
]}

CHANOCK, RM ^{[1
]}

机构：

[1] PLUM ISL ANIM DIS CTR,GREENPORT,NY 11944

来源：

SCIENCE | 1979年 / 203卷 / 4380期

关键词：

D O I：

10.1126/science.216077

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The possibility of immunizing human infants against rotaviruses, which cause severe dehydrating diarrheal disease, may depend on the use of a related rotavirus, derived from another animal species, as a source of antigen. To test the feasibility of this approach, calves were infected in utero with a bovine rotavirus and challenged with bovine or human type 2 rotavirus shortly after birth. Infection in utero with bovine rotavirus induced resistance to diarrheal disease caused by the human virus as well as the homologous bovine virus. These data suggest that the bovine virus is sufficiently related antigenically to the human type 2 virus to warrant further evaluation of the former as a source of vaccine. Copyright © 1979 AAAS.

引用

页码：548 / 550

页数：3

共 23 条

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[4] KAPIKIAN AZ, 1975, LANCET, V1, P1056
[5] KAPIKIAN AZ, UNPUBLISHED
[6] DIARRHEA IN GNOTOBIOTIC CALVES CAUSED BY REOVIRUS-LIKE AGENT OF HUMAN INFANTILE GASTROENTERITIS
MEBUS, CA
WYATT, RG
SHARPEE, RL
SERENO, MM
KALICA, AR
KAPIKIAN, AZ
TWIEHAUS, MJ
[J]. INFECTION AND IMMUNITY, 1976, 14 (02) : 471 - 474
[7] MEBUS CA, 1972, AM J VET RES, V33, P2335
[8] MEBUS CA, 1971, CANADIAN VET J, V12, P69
[9] NEWMAN LE, 1978, THESIS MICHIGAN STAT
[10] ROTAVIRUS INFECTION IN LAMBS - STUDIES ON PASSIVE PROTECTION
SNODGRASS, DR
WELLS, PW
[J]. ARCHIVES OF VIROLOGY, 1976, 52 (03) : 201 - 205

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