SCREENING-TEST FOR THE MALIGNANT HYPER-PYREXIA PHENOTYPE USING SUXAMETHONIUM-INDUCED CONTRACTURE OF MUSCLE TREATED WITH CAFFEINE, AND ITS INHIBITION BY DANTROLENE

被引：18

作者：

HALSALL, PJ

ELLIS, FR

机构：

[1] Malignant Hyperpyrexia Investigation Unit, University Department of Anaesthesia, St James's Hospital

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1979年 / 51卷 / 08期

关键词：

D O I：

10.1093/bja/51.8.753

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Suxamethonium induced a contracture in caffeine pretreated human muscle in vitro. The contracture was significantly greater (P < 0.001) with MHS muscle compared with muscle from normal subjects. This reaction is now used as an additional screening test for the MHS phenotype. The contracture was prevented by pretreatment with dantrolene. © 1979 Macmillan Journals Ltd.

引用

页码：753 / 756

页数：4

共 9 条

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