DEGRADATION OF ATRIAL-NATRIURETIC-FACTOR IN MOUSE-BLOOD INVITRO AND INVIVO - ROLE OF ENKEPHALINASE (EC 3.4.24.11)

被引：17

作者：

GROS, C

SOUQUE, A

SCHWARTZ, JC

机构：

[1] Unité de Neurobiologie et Pharmacologie (U. 109), l'INSERM Centre Paul Broca, 75014 Paris, 2ter, rue d'Alésia

来源：

NEUROPEPTIDES | 1990年 / 17卷 / 01期

关键词：

D O I：

10.1016/0143-4179(90)90133-J

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The half-life of 125I-ANF (99-126) in mouse blood in vivo, evaluated after HPLC analysis, was ∼0.5 min. This value was nearly doubled in mice pretreated with sinorphan, an enkephalinase inhibitor. 125I-ANF is also hydrolyzed by mouse blood in vitro but its half-life is much longer and only marginally modified by an enkephalinase inhibitor. Hence, although the peptidase is present in blood plasma and cells, its rate-limiting participation in the clearance of the hormone in vivo does not occur at the blood level. © 1990.

引用

页码：1 / 5

页数：5

共 33 条

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