INCREASE BY ALPHA-ADRENOLYTIC DRUGS OF ACETYLCHOLINE-RELEASE EVOKED BY FIELD STIMULATION OF THE GUINEA-PIG ILEUM

被引：29

作者：

KILBINGER, H

WESSLER, I

机构：

[1] Pharmakologisches Institut der Universität Mainz, Mainz, D-6500

来源：

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 1979年 / 309卷 / 03期

关键词：

Acetylcholine release; Myenteric plexus; Phentolamine; Tolazoline; Yohimbine;

D O I：

10.1007/BF00504758

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The release of acetylcholine evoked by field stimulation of the guinea-pig ileum (3 Hz) is increased by yohimbine and tolazoline but not affected by phentolamine. It is proposed that yohimbine and tolazoline by blocking α-adrenoceptors of the cholinergic nerves abolish the inhibition caused by endogenous noradrenaline, and thus facilitate the output of acetylcholine. © 1979 Springer-Verlag.

引用

收藏

页码：255 / 257

页数：3

相关论文

共 11 条

[1]

AHLQUIST RP, 1947, J PHARMACOL EXP THER, V89, P271

[2] COMPARISON OF PRESYNAPTIC AND POSTSYNAPTIC EFFECTS OF ALPHA-ADRENOLYTIC DRUGS IN PULMONARY-ARTERY OF RABBIT [J].

BOROWSKI, E ;

STARKE, K ;

EHRL, H ;

ENDO, T .

NEUROSCIENCE, 1977, 2 (02) :285-296

[3] PHARMACOLOGICAL CHARACTERIZATION OF PRESYNAPTIC ALPHA-ADRENOCEPTORS REGULATING CHOLINERGIC ACTIVITY IN GUINEA-PIG ILEUM [J].

DREW, GM .

BRITISH JOURNAL OF PHARMACOLOGY, 1978, 64 (02) :293-300

[4] EFFECTS OF MORPHINE ON RELEASE OF NORADRENALINE FROM CAT ISOLATED NICTITATING-MEMBRANE AND GUINEA-PIG ILEUM MYENTERIC PLEXUS LONGITUDINAL MUSCLE PREPARATION [J].

HENDERSON, G ;

HUGHES, J ;

KOSTERLITZ, HW .

BRITISH JOURNAL OF PHARMACOLOGY, 1975, 53 (04) :505-512

[5] GAS-CHROMATOGRAPHIC ESTIMATION OF ACETYLCHOLINE IN RABBIT HEART USING A NITROGEN SELECTIVE DETECTOR [J].

KILBINGER, H .

JOURNAL OF NEUROCHEMISTRY, 1973, 21 (02) :421-429

[6] FORMATION AND RELEASE OF ACETYLPYRROLIDINECHOLINE(N-METHYL, N-ACETOXYETHYLPYRROLIDINIUM) AS A FALSE CHOLINERGIC TRANSMITTER IN MYENTERIC PLEXUS OF GUINEA-PIG SMALL-INTESTINE [J].

KILBINGER, H .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1977, 296 (02) :153-158

[7]

NICKERSON M, 1967, PHYSIOL PHARMACOL, V4, P243

[8] INHIBITORY ACTION OF NORADRENALINE AND ADRENALINE ON ACETYLCHOLINE OUTPUT BY GUINEA-PIG ILEUM LONGITUDINAL MUSCLE STRIP [J].

PATON, WDM ;

VIZI, ES .

BRITISH JOURNAL OF PHARMACOLOGY, 1969, 35 (01) :10-&

[9] EFFECTS OF SYMPATHETIC NERVE STIMULATION AND GUANETHIDINE ON PARASYMPATHETIC NEUROEFFECTOR TRANSMISSION - INHIBITION OF ACETYLCHOLINE RELEASE [J].

VIZI, ES ;

KNOLL, J .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1971, 23 (12) :918-&

[10]

VIZI ES, 1976, SMOOTH MUSCLE, P357