NEW CLASS-II-LIKE GENES IN THE MURINE MHC

被引：119

作者：

CHO, SG

ATTAYA, M

MONACO, JJ

机构：

[1] Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond

来源：

NATURE | 1991年 / 353卷 / 6344期

关键词：

D O I：

10.1038/353573a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

MAJOR histocompatibility complex (MHC) class I molecules present endogenous antigens to CD8+ (cytotoxic) T cells. MHC class II molecules present primarily exogenously derived antigens to CD4+ T cells. Three new genes (Ma, Mb1 and Mb2) located between the Pb and Ob genes of the murine MHC have properties indicating that they are members of the MHC class II gene family, but they are the most divergent class II members so far identified and are almost as closely related in sequence to class I genes as they are to the known class II genes.

引用

页码：573 / 576

页数：4

共 23 条

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